DEVELOPMENT AND CHARACTERIZATION OF COMPRITOL ATO® BASE IN NANOSTRUCTURED LIPID CARRIERS FORMULATION WITH THE PROBE SONICATION METHOD

Objective: Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but it is highly lipophilic (log p±12.2) and potentially degraded. To overcome permeability stability problems, vitamin needs to be developed in Nanostructured Lipid Carrier (NLC), a nano-delivery system based on solid lipid liquid stabilized by surfactants as colloidal system.
 Methods: The formulation into NLC was carried out using hot homogenization method then sonicated probe sonicator. materials used were 2%, Compritol® 2-6%, Myritol® 1%, Plantacare® 1-3%. results characterized measuring particle size, zeta potential, polydispersity index, entrapment efficiency, its morphology.
 Results: characterization showed 280-375 nm potential was-23 mV to-28 mV, index was<0.5, efficiency 92-97%, morphological form spherical shape.
 Conclusion: show Nanosturctured Carriers shows good results.